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河豚毒素TETRODOTOXIN ( TTX )
Molecular Formula : C11H17N3O8 from Fugu Fish organs
Molecular Weight : 319.28
Chemical Name : Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-[1,3]dioxocino [6,5-d]pyrimidine-4,7,10,11,12-pentol
* Melting Point : does not melt at 200°C, darkens and black with increasing temperature.
* Solubility in : dilute acetic acid, dilute sulfuric acid, ethanol, or citrate buffer ( pH 4.8-4.9 ); slightly in water, dry alcohol and ether; insoluble in organic solvent.
* Purity min. : 99% ( HPLC, TLC-FID, IR, NMR ).
* Physical Form : white crystal powder.
Physical Form : white crystal powder.
* Biological Activity :
KD ( cardiac myocytes in rats ) : 0.8 nM(2)
* 10-8 M block nervous system; * 10-5 M block heart muscle. The binding to Na+ channel is reversible. ED50 = 3.7 nM.
* Toxicity ( LD50 ) :
mice ( i.v.) : 8.4 mg / kg. ;
mice ( i.p.) : 8.1 mg / kg. ;
mice ( s.c.) : 10.8 mg / kg.
* Storage recommendations :
stable at room temperature, store preferably at 4°C. Solid and solutions can be kept in deep freeze for a long time without any change in their activity. Solution for use: reconstitute in citrate or acetate buffer, pH 4.8-4.9 . Safety recommendations: highly toxic.
* CAS Reg. No. : 4368-28-9
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